Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 4/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18712103 | 0.85 | CTSK (0.38) | CTSKTDP1CA1CA2CA7 | |
| SCHEMBL30464727 | 0.84 | CTSK (0.41) | CTSKTDP1CA1CA2CA7 | |
| SCHEMBL2396853 | 0.81 | MEN1 (0.36) | CTSKTDP1CA1CA2CA7 | |
| SCHEMBL1207296 | 0.81 | CTSK (0.36) | CTSKTDP1CA1CA2CA7 | |
| SCHEMBL19787903 | 0.80 | PTPN11 (0.44) | CTSKTDP1CA1CA2CA7 | |
| SCHEMBL30975132 | 0.79 | CTSK (0.39) | CTSKTDP1CA1CA2CA7 | |
| SCHEMBL6692466 | 0.78 | PTPN11 (0.46) | CTSKTDP1CA1CA2CA7 | |
| SCHEMBL5728803 | 0.78 | CTSK (0.38) | CTSKTDP1CA1CA2CA7 | |
| SCHEMBL3348304 | 0.77 | TDP1 (0.49) | TDP1CA1CA2MAOAMAOB | |
| SCHEMBL6623918 | 0.76 | MEN1 (0.38) | CTSKTDP1CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |