Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 5/20 | 0.37 |
| ▸ | CA1 | P00915 | 5/20 | 0.36 |
| ▸ | CA2 | P00918 | 5/20 | 0.36 |
| ▸ | CTSS | P25774 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | CA9 | Q16790 | 4/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348304 | 0.89 | TDP1 (0.49) | PTPN11TDP1MAOAMAOBMEN1 | |
| SCHEMBL2143910 | 0.85 | PTPN11 (0.47) | PTPN11TDP1MAOAMAOBMEN1 | |
| SCHEMBL24145486 | 0.83 | MEN1 (0.46) | PTPN11TDP1MAOAMAOBMEN1 | |
| SCHEMBL13306434 | 0.83 | TDP1 (0.53) | PTPN11TDP1MAOAMAOBMEN1 | |
| SCHEMBL13306431 | 0.81 | PTPN11 (0.47) | PTPN11TDP1MAOAMAOBMEN1 | |
| SCHEMBL24094851 | 0.81 | PTPN11 (0.47) | PTPN11TDP1MAOAMAOBMEN1 | |
| SCHEMBL939491 | 0.80 | PTPN11 (0.47) | PTPN11TDP1MAOAMAOBMEN1 | |
| SCHEMBL19787902 | 0.80 | CTSK (0.36) | PTPN11TDP1MAOAMAOBMEN1 | |
| SCHEMBL13306409 | 0.79 | TDP1 (0.56) | PTPN11TDP1MAOAMAOBMEN1 | |
| SCHEMBL14404775 | 0.79 | CTSK (0.51) | PTPN11TDP1MAOAMAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |