Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350219 | 0.85 | ADRA1D (0.58) | PDPK1ALDH1A1KDM4EADRA1DUSP2 | |
| SCHEMBL31418373 | 0.82 | ADRA1D (0.52) | PDPK1ALDH1A1KDM4EABL1ADRA1D | |
| SCHEMBL3350356 | 0.80 | KMT2A (0.50) | PDPK1ALDH1A1KDM4EADRA1DUSP2 | |
| SCHEMBL15241737 | 0.79 | BRD4 (0.54) | ALDH1A1KDM4EADRA1DMAPK10POLB | |
| SCHEMBL3348293 | 0.77 | KDM4E (0.67) | ALDH1A1KDM4EADRA1DUSP2MAPK10 | |
| SCHEMBL4387866 | 0.74 | KDM4E (0.53) | PDPK1ALDH1A1KDM4EADRA1DGAA | |
| SCHEMBL12584181 | 0.74 | ALDH1A1 (0.42) | ALDH1A1KDM4EP2RX3PPARGPOLB | |
| SCHEMBL13307005 | 0.73 | POLB (0.41) | PDPK1ALDH1A1KDM4EADRA1DUSP2 | |
| SCHEMBL5183997 | 0.72 | MAPK10 (0.52) | PDPK1ALDH1A1KDM4EUSP2MAPK10 | |
| SCHEMBL15241726 | 0.71 | ALDH1A1 (0.39) | PDPK1ALDH1A1KDM4EUSP2MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |
| US-9873693-B2 | Methods of treatment using pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2018-01-23 | — | — | US | disclosed |