Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 2/20 | 0.31 |
| ▸ | CASP7 | P55210 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24997738 | 1.00 | MAPK14 (0.34) | MAPK14LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL19788774 | 0.92 | CASP1 (0.38) | MAPK14LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL19788776 | 0.88 | MAPK14 (0.34) | MAPK14LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL20079064 | 0.85 | ALDH1A1 (0.41) | MAPK14LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL19788778 | 0.84 | CDK8 (0.36) | MAPK14LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL16006485 | 0.84 | MAPT (0.37) | LMNAMAPTGAASMN1; SMN2KDM4E | |
| SCHEMBL16006561 | 0.84 | MAPT (0.37) | LMNAMAPTGAASMN1; SMN2KDM4E | |
| SCHEMBL19788827 | 0.83 | CNR2 (0.35) | MAPK14LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL22885167 | 0.83 | MAPT (0.33) | MAPK14LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL19788828 | 0.82 | KDM4E (0.36) | MAPK14LMNAMAPTGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9873680-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2018-01-23 | — | — | US | disclosed |