Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 15/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.54 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.54 |
| ▸ | CLK2 | P49760 | 5/20 | 0.51 |
| ▸ | CLK3 | P49761 | 5/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.51 |
| ▸ | WNT1 | P04628 | 2/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1981158 | 0.81 | PIM1 (0.51) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL1980913 | 0.81 | PIM1 (0.54) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL1983599 | 0.80 | PIM1 (0.62) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL12597370 | 0.78 | PIM1 (0.47) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL1987825 | 0.77 | PIM1 (0.53) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL12435346 | 0.75 | PIM1 (0.66) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL1980257 | 0.75 | PIM1 (0.52) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL9427509 | 0.74 | IMPDH2 (0.62) | PIM1 | |
| SCHEMBL473761 | 0.74 | PIM1 (0.61) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL1978726 | 0.74 | PIM1 (0.51) | PIM1PIM2PIM3CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |