Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 11/20 | 0.62 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.62 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.62 |
| ▸ | CLK2 | P49760 | 2/20 | 0.56 |
| ▸ | CLK3 | P49761 | 2/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.56 |
| ▸ | WNT1 | P04628 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.56 |
| ▸ | TDO2 | P48775 | 2/20 | 0.55 |
| ▸ | GABRP | O00591 | 2/20 | 0.54 |
| ▸ | GABRD | O14764 | 2/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.54 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.54 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.54 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.54 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10647099 | 0.86 | GABRP (0.60) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL473761 | 0.85 | PIM1 (0.61) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL1980810 | 0.85 | PIM1 (0.57) | PIM1TDO2GABRPGABRDGABRA1 | |
| SCHEMBL1980603 | 0.85 | CHUK (0.58) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL1981058 | 0.85 | CHUK (0.58) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL12938276 | 0.82 | GABRP (0.68) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL1981367 | 0.81 | PIM1 (0.64) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL1984452 | 0.81 | FHIT (0.55) | PIM1PIM2PIM3CLK2CLK3 | |
| SCHEMBL1980243 | 0.81 | CHUK (0.61) | PIM1PIM2PIM3CLK2DYRK1A | |
| SCHEMBL1559845 | 0.81 | GABRP (0.58) | PIM1PIM2PIM3CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | claimed |
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |