Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.44 |
| ▸ | WNT1 | P04628 | 5/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 4/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.41 |
| ▸ | NRAS | P01111 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12597832 | 0.92 | DYRK1A (0.45) | PIM1DYRK1AWNT1 | |
| SCHEMBL1978545 | 0.88 | IGF1R (0.41) | PIM1DYRK1AWNT1 | |
| SCHEMBL12597625 | 0.87 | IGF1R (0.43) | PIM1DYRK1AWNT1 | |
| SCHEMBL12598118 | 0.84 | — | — | |
| SCHEMBL12597359 | 0.83 | SLC2A1 (0.45) | PIM1 | |
| SCHEMBL1983761 | 0.83 | BRAF (0.47) | PIM1DYRK1AWNT1 | |
| SCHEMBL1981803 | 0.82 | MTNR1A (0.45) | PIM1 | |
| SCHEMBL1980514 | 0.82 | PIM1 (0.44) | PIM1DYRK1A | |
| SCHEMBL1980453 | 0.82 | SUV39H2 (0.43) | SUV39H2CHEK2MET | |
| SCHEMBL1981315 | 0.82 | PTAFR (0.47) | DYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |