Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.41 |
| ▸ | WNT1 | P04628 | 4/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12597832 | 0.92 | DYRK1A (0.45) | WNT1DYRK1APIM1TLR7 | |
| SCHEMBL12597625 | 0.88 | IGF1R (0.43) | IGF1RWNT1DYRK1APIM1TLR7 | |
| SCHEMBL1979009 | 0.88 | PIM1 (0.46) | WNT1DYRK1APIM1 | |
| SCHEMBL12598118 | 0.86 | — | — | |
| SCHEMBL1979171 | 0.85 | WNT1 (0.42) | WNT1DYRK1ATLR7 | |
| SCHEMBL12597359 | 0.84 | SLC2A1 (0.45) | PIM1TLR7SMPD1HPSEPIM3 | |
| SCHEMBL1983761 | 0.84 | BRAF (0.47) | WNT1DYRK1APIM1TLR7SMPD1 | |
| SCHEMBL1979088 | 0.84 | WNT1 (0.51) | IGF1RWNT1DYRK1ATLR7 | |
| SCHEMBL11908594 | 0.83 | DYRK1A (0.43) | WNT1DYRK1APIM1PIM3PIM2 | |
| SCHEMBL1979090 | 0.83 | ABL1 (0.47) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |