Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.60 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.57 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.57 |
| ▸ | STS | P08842 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ESR1 | P03372 | 3/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.52 |
| ▸ | SHBG | P04278 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979067 | 1.00 | USP2 (0.76) | USP2MAPTMAPK1HRH3HSD17B1 | |
| SCHEMBL12379442 | 1.00 | USP2 (0.76) | USP2MAPTMAPK1HRH3HSD17B1 | |
| SCHEMBL2290207 | 0.92 | USP2 (0.80) | USP2MAPTMAPK1HRH3HSD17B1 | |
| SCHEMBL12379451 | 0.92 | USP2 (0.80) | USP2MAPTMAPK1HRH3HSD17B1 | |
| SCHEMBL7518219 | 0.92 | USP2 (0.80) | USP2MAPTMAPK1HRH3HSD17B1 | |
| SCHEMBL12379469 | 0.89 | USP2 (0.72) | USP2MAPTMAPK1HRH3HSD17B1 | |
| SCHEMBL12379467 | 0.89 | USP2 (0.72) | USP2MAPTMAPK1HRH3HSD17B1 | |
| SCHEMBL2291026 | 0.89 | USP2 (0.72) | USP2MAPTMAPK1HRH3HSD17B1 | |
| SCHEMBL12419867 | 0.88 | USP2 (0.74) | USP2MAPTMAPK1HRH3HSD17B1 | |
| SCHEMBL2363362 | 0.88 | USP2 (0.68) | USP2MAPTMAPK1HRH3HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003783-B2 | Steroid 17 beta -hydroxysteroid dehydrogenase inhibitors substituted with one or more oxime groups, especially aromatase inhibitors used in the treatment of endocrine-dependent tumors, especially breast cancer | STERIX LIMITED (GB) | 2011-08-23 | — | — | US | disclosed |
| EP-2336146-A1 | 17beta-hydroxysteroid dehydrogenase inhibitors | Sterix Limited (GB) | 2011-06-22 | — | — | EP | disclosed |
| US-20060074060-A1 | Compound | STERIX LIMITED (GB) | 2006-04-06 | — | — | US | disclosed |
| EP-1631579-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Sterix Limited (GB) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004085457-A2 | 17BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS | STERIX LIMITED (GB) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074060-A1 | Compound | HAT1, CBR3, ADH5 | USP2 4567/4885MAPT 1534/4885MAPK1 2039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.