Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19790420 | 0.85 | SYK (0.51) | IRAK4SYKALDH1A1NPC1RAB9A | |
| SCHEMBL14929079 | 0.84 | TRPA1 (0.40) | JAK2JAK1IRAK4SYKGRM4 | |
| SCHEMBL14910328 | 0.82 | GRM4 (0.42) | JAK2JAK1SYKGRM4ALDH1A1 | |
| SCHEMBL14928547 | 0.82 | GRM4 (0.42) | JAK2JAK1SYKGRM4ALDH1A1 | |
| SCHEMBL14929941 | 0.80 | HPGD (0.46) | JAK2JAK1SYKGRM4ALDH1A1 | |
| SCHEMBL19790110 | 0.79 | JAK3 (0.34) | JAK2KDM4E | |
| SCHEMBL14910387 | 0.79 | GRM4 (0.41) | JAK2JAK1SYKGRM4ALDH1A1 | |
| SCHEMBL14910389 | 0.79 | GRM4 (0.41) | JAK2JAK1SYKGRM4ALDH1A1 | |
| SCHEMBL14910413 | 0.79 | IRAK4 (0.37) | JAK2JAK1IRAK4SYKGRM4 | |
| SCHEMBL14928328 | 0.79 | HPGD (0.44) | JAK2JAK1SYKGRM4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2799431-B1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORP (JP) | 2018-01-24 | — | — | EP | disclosed |