Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | MUSK | O15146 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19790695 | 0.79 | JAK2 (0.38) | JAK2KDM4E | |
| SCHEMBL19790355 | 0.78 | KDM4E (0.33) | JAK3JAK2LIMK1LIMK2KDM4E | |
| SCHEMBL19790434 | 0.78 | — | — | |
| SCHEMBL19790127 | 0.77 | MUSK (0.30) | JAK3MUSKNTRK1LCKRET | |
| SCHEMBL19790690 | 0.76 | JAK3 (0.36) | JAK3MUSKNTRK1LCKRET | |
| SCHEMBL19790111 | 0.74 | CACNA1H (0.36) | JAK3MUSKNTRK1LCKRET | |
| SCHEMBL19790227 | 0.74 | — | — | |
| SCHEMBL16170690 | 0.72 | TRPA1 (0.37) | JAK3MUSKNTRK1LCKRET | |
| SCHEMBL16169157 | 0.71 | TRPA1 (0.40) | JAK3MUSKNTRK1LCKRET | |
| SCHEMBL19790345 | 0.71 | KDM4E (0.33) | JAK3JAK2PLK1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2799431-B1 | NOVEL NICOTINAMIDE DERIVATIVE OR SALT THEREOF | FUJIFILM CORP (JP) | 2018-01-24 | — | — | EP | disclosed |