Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21408281 | 0.80 | CXCR2 (0.38) | MEN1KMT2ALMNACYP1A2PTGS1 | |
| SCHEMBL17593323 | 0.78 | MAOB (0.49) | MEN1KMT2ALMNACYP1A2PTGS1 | |
| SCHEMBL511881 | 0.72 | BCHE (0.40) | SLC6A4MEN1KMT2ALMNACYP1A2 | |
| SCHEMBL8782204 | 0.71 | ALOX5 (0.40) | PLAUSLC6A4LMNACYP1A2PTGS1 | |
| SCHEMBL1202097 | 0.70 | LTA4H (0.46) | LMNACYP1A2PTGS1SLC6A2CYP2C19 | |
| SCHEMBL4288596 | 0.70 | PLAU (0.46) | PLAUSLC6A4PIN1MEN1KMT2A | |
| SCHEMBL9481827 | 0.67 | ALOX5 (0.42) | PLAUMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL7972246 | 0.66 | CYP1A2 (0.38) | MEN1KMT2ALMNACYP1A2TSHR | |
| SCHEMBL457443 | 0.66 | P4HTM (0.53) | PIN1LMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL9479747 | 0.66 | MAPT (0.42) | PLAULMNACYP1A2PTGS1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | claimed |
| WO-2011072064-A1 | S PIRO [CHROMAN - 4, 4 ' - IMIDAZOL] ONES AS BETA - SECRETASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-06-16 | — | — | WO | disclosed |