SCHEMBL1979087

SCHEMBL1979087

C=C(C)C(=O)Nc1ccc(CCOC(=O)C(=C)C)cc1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.49
THRB P10828 1/20 0.42
FGFR1 P11362 1/20 0.41
FGFR4 P22455 1/20 0.41
TDP1 Q9NUW8 3/20 0.41
BAZ1A Q9NRL2 1/20 0.40
MAPT P10636 2/20 0.40
POLB P06746 4/20 0.39
APEX1 P27695 1/20 0.39
HTT P42858 1/20 0.39
HRH3 Q9Y5N1 1/20 0.39
TSHR P16473 3/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
RECQL P46063 1/20 0.38
BLM P54132 1/20 0.38
LMNA P02545 1/20 0.38
AOC3 Q16853 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11921516 0.86 THRB (0.55) THRBTDP1MAPTPOLBAPEX1
SCHEMBL24788142 0.85 THRB (0.45) THRBTDP1MAPTPOLBAPEX1
SCHEMBL22566492 0.84 THRB (0.53) THRBTDP1MAPTPOLBAPEX1
SCHEMBL13756064 0.83 RXFP1 (0.44) RXFP1FGFR1FGFR4TDP1BAZ1A
SCHEMBL16693229 0.82 CYP17A1 (0.52) L3MBTL1
SCHEMBL10457799 0.81 THRB (0.50) THRBTDP1MAPTPOLBAPEX1
SCHEMBL13221752 0.80 THRB (0.49) THRBTDP1MAPTPOLBAPEX1
SCHEMBL8604610 0.80 RXFP1 (0.56) RXFP1THRBFGFR1FGFR4TDP1
SCHEMBL1119186 0.80 NPC1 (0.51) THRBTDP1MAPTPOLBAPEX1
SCHEMBL296203 0.80 CA1 (0.49) THRBTDP1MAPTPOLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3368285-B1 METHOD OF MAKING OPTICAL ARTICLES HAVING GRADIENT LIGHT INFLUENCING PROPERTIES TRANSITIONS OPTICAL INC (US) 2026-04-15 EP disclosed
EP-3368927-B1 OPTICAL ARTICLE WITH GRADIENT LIGHT INFLUENCING PROPERTIES AND METHOD OF MAKING THE SAME TRANSITIONS OPTICAL INC (US) 2024-10-16 EP disclosed
US-12076951-B2 Method of making optical articles having gradient light influencing properties TRANSITIONS OPTICAL, INC. (US) 2024-09-03 US disclosed
US-12055741-B2 Optical articles and method of preparing the same TRANSITIONS OPTICAL, INC. (US) 2024-08-06 US disclosed
EP-3368926-B1 A METHOD OF MAKING AN OPTICAL ARTICLE WITH AN INKJET PRINTING DEVICE TRANSITIONS OPTICAL LTD (IE) 2024-03-06 EP disclosed
US-11714220-B2 Optical article with gradient light influencing properties and method of making the same TRANSITIONS OPTICAL, INC. (US) 2023-08-01 US disclosed
US-20220171110-A1 Optical Articles and Method of Preparing the Same TRANSITIONS OPTICAL, INC. 2022-06-02 US disclosed
US-20220066081-A1 Optical Article with Gradient Light Influencing Properties and Method of Making the Same TRANSITIONS OPTICAL, INC. 2022-03-03 US disclosed
US-11256014-B2 Optical articles and method of preparing the same TRANSITIONS OPTICAL, INC. (US) 2022-02-22 US disclosed
US-10590220-B2 Photoalignment materials having improved adhesion TRANSITIONS OPTICAL, INC. (US) 2020-03-17 US disclosed
US-20170037173-A1 Photoalignment Materials Having Improved Adhesion TRANSITIONS OPTICAL, INC. 2017-02-09 US disclosed
EP-2510023-B1 PHOTOALIGNMENT MATERIALS HAVING IMPROVED ADHESION TRANSITIONS OPTICAL INC (US) 2013-09-11 EP disclosed
EP-2510023-A1 PHOTOALIGNMENT MATERIALS HAVING IMPROVED ADHESION Transitions Optical, Inc. (US) 2012-10-17 EP disclosed
WO-2011071794-A1 PHOTOALIGNMENT MATERIALS HAVING IMPROVED ADHESION TRANSITIONS OPTICAL, INC. (US) 2011-06-16 WO disclosed