Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 4/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | USP7 | Q93009 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 5/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | BCR | P11274 | 1/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636363 | 0.84 | KIF11 (0.41) | KIF11ARAPP | |
| SCHEMBL2433534 | 0.84 | PDE3B (0.36) | KIF11ARPDE3BPDE3APGR | |
| SCHEMBL6513960 | 0.82 | PDE3B (0.37) | ARPDE3BPDE3A | |
| SCHEMBL1369645 | 0.81 | KIF11 (0.38) | KIF11AR | |
| SCHEMBL9586467 | 0.81 | APP (0.43) | KIF11ARHSD17B1HSD17B2APP | |
| SCHEMBL14483362 | 0.80 | GLA (0.38) | — | |
| SCHEMBL8821891 | 0.79 | KIF11 (0.42) | KIF11PDE3BPDE3A | |
| SCHEMBL7955020 | 0.78 | PGR (0.47) | ARESR2PGRABL1ABCB1 | |
| SCHEMBL2431534 | 0.76 | PDE3B (0.40) | KIF11ARPDE3BPDE3A | |
| SCHEMBL4669684 | 0.76 | AKR1C3 (0.48) | KIF11ARAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509978-A1 | AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | E.I. Du Pont De Nemours And Company (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072207-A1 | AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-06-16 | — | — | WO | disclosed |