Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 12/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | GRK5 | P34947 | 14/20 | 0.47 |
| ▸ | GRK2 | P25098 | 11/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12441181 | 0.82 | MET (0.56) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL12440246 | 0.81 | MET (0.56) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL19791642 | 0.81 | MET (0.51) | METKCNH2GRK5GRK2FLT3 | |
| Hydrochloric Acid SCHEMBL2328784 | 0.81 | MET (0.55) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL3476130 | 0.72 | MAP4K3 (0.65) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL2324841 | 0.71 | MAP4K3 (0.47) | METNTRK1 | |
| SCHEMBL2385882 | 0.71 | MET (0.77) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL2320474 | 0.71 | MAP4K1 (0.53) | METKCNH2GRK5GRK2FLT3 | |
| Hydrochloric Acid SCHEMBL13834975 | 0.70 | MAP4K1 (0.52) | METKCNH2GRK5GRK2FLT3 | |
| SCHEMBL2321067 | 0.70 | INPPL1 (0.50) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2531500-B1 | HETARYL-[1,8]NAPHTHYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-01-24 | — | — | EP | disclosed |