Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13268463 | 0.82 | BACE1 (0.40) | BACE1BACE2 | |
| SCHEMBL1980478 | 0.82 | BACE2 (0.47) | BACE1BACE2 | |
| SCHEMBL1980085 | 0.78 | BACE1 (0.43) | BACE1BACE2 | |
| SCHEMBL13859176 | 0.78 | BACE1 (0.55) | BACE1BACE2 | |
| SCHEMBL1979636 | 0.74 | BACE1 (0.61) | BACE1BACE2 | |
| SCHEMBL1980684 | 0.74 | BACE1 (0.35) | BACE1BACE2 | |
| SCHEMBL1979488 | 0.73 | BACE1 (0.44) | BACE1BACE2 | |
| SCHEMBL1978992 | 0.73 | BACE1 (0.65) | BACE1BACE2 | |
| SCHEMBL1978259 | 0.73 | BACE1 (0.62) | BACE1BACE2 | |
| SCHEMBL1977845 | 0.73 | BACE1 (0.67) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709992-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012156284-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-22 | — | — | WO | disclosed |
| EP-2509966-A1 | AMINO OXAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011070029-A1 | AMINO OXAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |