Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.47 |
| ▸ | BACE1 | P56817 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978685 | 0.84 | BACE2 (0.44) | BACE2BACE1ALDH1A1HIF1ATDP1 | |
| SCHEMBL1979166 | 0.82 | BACE1 (0.42) | BACE2BACE1 | |
| SCHEMBL13268463 | 0.78 | BACE1 (0.40) | BACE2BACE1 | |
| SCHEMBL14165303 | 0.77 | BACE2 (0.44) | BACE2BACE1ALDH1A1HIF1ATDP1 | |
| SCHEMBL1979221 | 0.77 | BACE2 (0.44) | BACE2BACE1ALDH1A1HIF1ATDP1 | |
| SCHEMBL13278685 | 0.77 | BACE2 (0.44) | BACE2BACE1ALDH1A1HIF1ATDP1 | |
| SCHEMBL13278513 | 0.76 | BACE1 (0.43) | BACE2BACE1ALDH1A1HIF1ATDP1 | |
| SCHEMBL13278476 | 0.76 | BACE1 (0.43) | BACE2BACE1ALDH1A1HIF1ATDP1 | |
| SCHEMBL4320848 | 0.76 | ALDH1A1 (0.50) | BACE2BACE1ALDH1A1HIF1ATDP1 | |
| SCHEMBL1978652 | 0.75 | SIRT2 (0.38) | BACE2BACE1ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709992-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012156284-A1 | 1,3-OXAZINES AS BACE1 AND/OR BACE2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-22 | — | — | WO | disclosed |
| EP-2509966-A1 | AMINO OXAZINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011070029-A1 | AMINO OXAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-16 | — | — | WO | disclosed |