Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 8/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979472 | 0.95 | S1PR1 (0.47) | S1PR1S1PR5S1PR4S1PR3PDCD1 | |
| SCHEMBL1978012 | 0.90 | S1PR1 (0.46) | S1PR1S1PR5S1PR4S1PR3PDCD1 | |
| SCHEMBL1977547 | 0.86 | S1PR1 (0.51) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL1978561 | 0.86 | S1PR1 (0.51) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL1981594 | 0.79 | S1PR1 (0.49) | S1PR1S1PR5S1PR4S1PR3SIGMAR1 | |
| SCHEMBL1978057 | 0.76 | S1PR5 (0.48) | S1PR1S1PR5S1PR4S1PR3SLC6A9 | |
| SCHEMBL1978594 | 0.76 | S1PR1 (0.46) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL1981574 | 0.76 | SLC6A9 (0.50) | S1PR1S1PR5S1PR4S1PR3SLC6A9 | |
| SCHEMBL1981219 | 0.75 | S1PR1 (0.49) | S1PR1S1PR5S1PR4S1PR3 | |
| SCHEMBL1978218 | 0.75 | S1PR5 (0.55) | S1PR1S1PR5S1PR4S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504328-A1 | NOVEL COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | Allergan, Inc. (US) | 2012-10-03 | — | — | EP | claimed |
| WO-2011066179-A1 | NOVEL COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | ALLERGAN, INC. (US) | 2011-06-03 | — | — | WO | claimed |