Sugi Predict

Sugi Predict / Compounds / SCHEMBL19795207

SCHEMBL19795207

SCHEMBL19795207

Cn1[nH]c(=O)c2ccc(Br)cc21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TP53 P04637 2/20 0.43
▸ METAP2 P50579 1/20 0.43
▸ KDM4E B2RXH2 1/20 0.43
▸ CHEK1 O14757 3/20 0.39
▸ PDGFRA P16234 2/20 0.39
▸ CDK5 Q00535 2/20 0.39
▸ TYRO3 Q06418 2/20 0.39
▸ PIM1 P11309 2/20 0.39
▸ FLT3 P36888 2/20 0.39
▸ AURKA O14965 1/20 0.39
▸ DAPK3 O43293 1/20 0.39
▸ JAK2 O60674 1/20 0.39
▸ PRKD3 O94806 1/20 0.39
▸ MAP4K4 O95819 1/20 0.39
▸ PAK4 O96013 1/20 0.39
▸ ABL1 P00519 1/20 0.39
▸ NTRK1 P04629 1/20 0.39
▸ CSF1R P07333 1/20 0.39
▸ RET P07949 1/20 0.39
▸ MET P08581 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31073071 1.00 TP53 (0.43) TP53METAP2KDM4ECHEK1PDGFRA
SCHEMBL17141572 0.85 CHEK1 (0.43) TP53METAP2KDM4ECHEK1PDGFRA
SCHEMBL30900403 0.85 CHEK1 (0.43) TP53METAP2KDM4ECHEK1PDGFRA
SCHEMBL2267451 0.79 KDM4E (0.44) TP53KDM4ECHEK1PIM1RPS6KA3
SCHEMBL2268831 0.78 MAT2A (0.43) TP53KDM4ENTRK1LMNADAO
SCHEMBL2268619 0.77 DAO (0.41) TP53METAP2CHEK1PDGFRACDK5
SCHEMBL14692230 0.75 METAP2 (0.44) METAP2CHEK1CAMK2AEGLN1PTGES
SCHEMBL30015488 0.75 METAP2 (0.44) METAP2CHEK1CAMK2AEGLN1PTGES
SCHEMBL22156294 0.75 KDM4E (0.44) TP53KDM4ECDK5TYRO3FLT3
SCHEMBL2547471 0.73 TSHR (0.53) METAP2POLBLMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119751392-A Benzofuran compound or pharmaceutically acceptable salt thereof, and preparation method and application thereof 南方医科大学 2025-04-04 — — CN disclosed
US-20240246950-A1 Anilino-Pyrazole Derivatives, Compositions and Methods Thereof Ensem Therapeutics (US) 2024-07-25 — — US disclosed
US-20180022746-A1 INDAZOLE AND AZAINDAZOLE SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION VANDERBILT UNIVERSITY 2018-01-25 — — US disclosed
US-20180022746-A1 INDAZOLE AND AZAINDAZOLE SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION VANDERBILT UNIVERSITY 2018-01-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180022746-A1 INDAZOLE AND AZAINDAZOLE SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION GRIK4, GRM4, GRIA4 TP53 4578/4885METAP2 3939/4885KDM4E 990/4885
US-20240246950-A1 Anilino-Pyrazole Derivatives, Compositions and Methods Thereof CDK2, CDK3, CDK4 TP53 179/4885METAP2 3169/4885KDM4E 1787/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.