Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 12/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.45 |
| ▸ | FHIT | P49789 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | WEE1 | P30291 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | CLK3 | P49761 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11907943 | 0.88 | MKNK1 (0.46) | MKNK1MKNK2PIM1PIM2PIM3 | |
| SCHEMBL1980514 | 0.85 | PIM1 (0.44) | MKNK1MKNK2PIM1PIM2PIM3 | |
| SCHEMBL1981391 | 0.85 | PIM1 (0.51) | PIM1PIM2PIM3CHEK1WEE1 | |
| SCHEMBL1980196 | 0.83 | WNT1 (0.50) | PIM1PIM2PIM3DYRK1A | |
| SCHEMBL1981158 | 0.81 | PIM1 (0.51) | PIM1PIM2PIM3CHEK1WEE1 | |
| SCHEMBL12597204 | 0.81 | HDAC4 (0.39) | PIM1CLK2CLK3DYRK1A | |
| SCHEMBL1984452 | 0.81 | FHIT (0.55) | MKNK1MKNK2PIM1PIM2PIM3 | |
| SCHEMBL11908668 | 0.79 | CHEK1 (0.44) | PIM1PIM2PIM3CHEK1CLK2 | |
| SCHEMBL13190763 | 0.78 | SLC2A1 (0.46) | PIM1PIM2PIM3CHEK1CLK2 | |
| SCHEMBL11929477 | 0.78 | PIM1 (0.54) | PIM1PIM2PIM3CHEK1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |