Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19795949 | 0.94 | KMT2A (0.41) | NPC1RAB9AKMT2AMEN1CES2 | |
| SCHEMBL19795961 | 0.91 | ALDH1A1 (0.43) | NPC1KMT2AMEN1CES2CES1 | |
| SCHEMBL19795925 | 0.87 | ESRRG (0.40) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL19796009 | 0.87 | ALDH1A1 (0.42) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL19795922 | 0.85 | HPGD (0.44) | NPC1RAB9AKMT2AMAPTALDH1A1 | |
| SCHEMBL19041287 | 0.84 | CES2 (0.51) | NPC1RAB9AKMT2AMEN1CES2 | |
| SCHEMBL19796014 | 0.84 | HTT (0.41) | KMT2AMEN1CES2CES1MAPT | |
| SCHEMBL19795955 | 0.84 | ALDH1A1 (0.40) | KMT2AMEN1CES2CES1MAPT | |
| SCHEMBL19795937 | 0.84 | CA12 (0.38) | KMT2ACES1MAPTALDH1A1HPGD | |
| SCHEMBL19796017 | 0.84 | CA12 (0.39) | NPC1RAB9AKMT2AMEN1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180022693-A1 | COMPOUNDS | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180022693-A1 | COMPOUNDS | ERCC4, NQO1, ERCC5 | NPC1 316/4885RAB9A 1580/4885KMT2A 2823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.