Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 12/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.48 |
| ▸ | CBFB | Q13951 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979863 | 0.86 | PIM1 (0.50) | PIM1PIM2PIM3DYRK1ACLK2 | |
| SCHEMBL1980243 | 0.84 | CHUK (0.61) | NPY5RPIM1PIM2PIM3DYRK1A | |
| SCHEMBL1981367 | 0.82 | PIM1 (0.64) | NPY5RPIM1PIM2PIM3DYRK1A | |
| SCHEMBL1980603 | 0.80 | CHUK (0.58) | PIM1PIM2PIM3DYRK1ACLK2 | |
| SCHEMBL1983599 | 0.79 | PIM1 (0.62) | PIM1PIM2PIM3DYRK1AIDO1 | |
| SCHEMBL1981058 | 0.78 | CHUK (0.58) | PIM1PIM2PIM3DYRK1ACLK2 | |
| SCHEMBL1560934 | 0.76 | CHEK1 (0.52) | PIM1PIM2PIM3DYRK1ACLK2 | |
| SCHEMBL12594228 | 0.76 | CYP19A1 (0.54) | PIM1PIM2PIM3DYRK1ACLK2 | |
| SCHEMBL1981774 | 0.75 | PIM1 (0.51) | PIM1PIM2PIM3DYRK1ACLK2 | |
| SCHEMBL1984452 | 0.75 | FHIT (0.55) | PIM1PIM2PIM3DYRK1ACLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | claimed |
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |