Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CCR9 | P51686 | 10/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ACACA | Q13085 | 1/20 | 0.33 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.33 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979661 | 0.96 | BRD4 (0.38) | BRD4CCR9CNR2P2RY14HCRTR2 | |
| SCHEMBL12598985 | 0.86 | MEN1 (0.38) | BRD4MAPT | |
| SCHEMBL14904448 | 0.84 | MEN1 (0.37) | BRD4CNR2 | |
| SCHEMBL1977977 | 0.82 | MEN1 (0.39) | BRD4MAPT | |
| SCHEMBL14904443 | 0.80 | MEN1 (0.38) | BRD4HCRTR2 | |
| SCHEMBL1983809 | 0.78 | ALDH1A1 (0.37) | BRD4HCRTR2MAPT | |
| SCHEMBL14904457 | 0.77 | MEN1 (0.36) | CNR2MAPT | |
| SCHEMBL1978852 | 0.77 | ATM (0.39) | MAPT | |
| SCHEMBL12598785 | 0.72 | BRD4 (0.42) | BRD4CNR2MAPT | |
| SCHEMBL15177759 | 0.71 | AKT1 (0.35) | BRD4CNR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509980-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | Boehringer Ingelheim International GmbH (DE) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011071716-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-16 | — | — | WO | disclosed |