Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 17/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12597612 | 0.88 | PIM1 (0.44) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1979339 | 0.87 | CHUK (0.51) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1983392 | 0.83 | PIM1 (0.45) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1984089 | 0.82 | PIM1 (0.44) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL2031456 | 0.82 | PIM1 (0.39) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1981543 | 0.81 | PIM1 (0.49) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1983422 | 0.81 | CHEK1 (0.42) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL12597376 | 0.76 | PIM1 (0.48) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL12597806 | 0.75 | GSK3B (0.39) | PIM1CHEK1LRRK2 | |
| SCHEMBL12597810 | 0.75 | AXL (0.37) | CHEK1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |