Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | PRKCB | P05771 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | PRKCH | P24723 | 1/20 | 0.51 |
| ▸ | PRKCI | P41743 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 10/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1983392 | 0.90 | PIM1 (0.45) | CHUKPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL1984089 | 0.89 | PIM1 (0.44) | CHUKPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL12597376 | 0.87 | PIM1 (0.48) | PIM1MAP4K1PIM3PIM2MAPT | |
| SCHEMBL1979707 | 0.87 | PIM1 (0.44) | PIM1PIM3PIM2MAPTLRRK2 | |
| SCHEMBL1982964 | 0.84 | MAP4K1 (0.54) | PIM1MAP4K1PIM3PIM2MAPT | |
| SCHEMBL1982173 | 0.80 | CHEK1 (0.45) | PIM1MAP4K1PIM3PIM2MAPT | |
| SCHEMBL1978967 | 0.79 | PIM1 (0.61) | CHUKPIM1MAP4K1PIM3PIM2 | |
| SCHEMBL1981764 | 0.79 | CHUK (0.61) | CHUKPRKD3PRKCGPRKCBPRKCA | |
| SCHEMBL1979541 | 0.79 | MAP4K1 (0.49) | PIM1MAP4K1PIM3PIM2MAPT | |
| SCHEMBL12597612 | 0.76 | PIM1 (0.44) | PIM1PIM3PIM2MAPTLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070299-A1 | TRI-SUBSTITUTED 9H-BETA-CARBOLINE (OR 9H-PYRIDO[3,4-B]INDOLE) DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |