Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 14/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2214724 | 0.88 | CHEK1 (0.57) | CHEK1ACHEPIM1MAPT | |
| SCHEMBL1979638 | 0.88 | PIM1 (0.44) | CHEK1ACHEPIM1PIM3PIM2 | |
| SCHEMBL2215993 | 0.77 | CHEK1 (0.53) | CHEK1ACHEPIM1PIM3PIM2 | |
| SCHEMBL1979380 | 0.74 | PIM1 (0.58) | CHEK1ACHEPIM1PIM3PIM2 | |
| SCHEMBL2216558 | 0.74 | CHEK1 (0.54) | CHEK1ACHEPIM1PIM3PIM2 | |
| SCHEMBL1559867 | 0.72 | CHEK1 (0.51) | CHEK1ACHEPIM1PIM3PIM2 | |
| SCHEMBL1978967 | 0.72 | PIM1 (0.61) | CHEK1ACHEPIM1PIM3PIM2 | |
| SCHEMBL1559826 | 0.71 | PIM1 (0.43) | CHEK1ACHEPIM1MAPT | |
| SCHEMBL12666733 | 0.71 | CHEK1 (0.69) | CHEK1ACHEPIM1PIM3PIM2 | |
| SCHEMBL1979641 | 0.70 | CHEK1 (0.63) | CHEK1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | claimed |
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |