Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21656355 | 0.87 | KDM4E (0.46) | KCNN4POLBMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3671448 | 0.83 | PIN1 (0.49) | KCNN4POLBMAPTSMN1; SMN2PIN1 | |
| SCHEMBL17420423 | 0.81 | POLB (0.51) | KCNN4POLBLMNAMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL17825610 | 0.81 | MAPT (0.43) | KCNN4LMNAMAPTSMN1; SMN2TDP1 | |
| SCHEMBL5004403 | 0.79 | POLB (0.47) | KCNN4POLBLMNAMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL31084739 | 0.78 | XPO1 (0.39) | MAPTALDH1A1CNR2 | |
| SCHEMBL17999493 | 0.78 | POLB (0.43) | KCNN4POLBLMNAMAPTSMN1; SMN2 | |
| SCHEMBL19797977 | 0.78 | MAPT (0.47) | KCNN4POLBLMNAMAPTSMN1; SMN2 | |
| SCHEMBL17999316 | 0.77 | MAPT (0.46) | KCNN4POLBLMNAMAPTSMN1; SMN2 | |
| SCHEMBL29145552 | 0.76 | POLB (0.47) | KCNN4POLBLMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180022747-A1 | Factor IXa Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180022747-A1 | Factor IXa Inhibitors | F9, TFPI, F12 | KCNN4 1710/4885POLB 3869/4885LMNA 1124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.