Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6688835 | 1.00 | TSHR (0.60) | TSHRALDH1A1L3MBTL1MAPK1HIF1A | |
| SCHEMBL4328254 | 1.00 | TSHR (0.60) | TSHRALDH1A1L3MBTL1MAPK1HIF1A | |
| SCHEMBL28020204 | 0.85 | HSD17B10 (0.55) | TSHRALDH1A1L3MBTL1BRD4GPX4 | |
| SCHEMBL8019231 | 0.81 | TSHR (0.60) | TSHRALDH1A1MAPK1HIF1ALMNA | |
| SCHEMBL7262475 | 0.78 | ESR1 (0.62) | TSHRALDH1A1HIF1ATDP1ESR1 | |
| SCHEMBL4319988 | 0.78 | ESR1 (0.62) | TSHRALDH1A1HIF1ATDP1ESR1 | |
| SCHEMBL467691 | 0.78 | ESR1 (0.62) | TSHRALDH1A1HIF1ATDP1ESR1 | |
| SCHEMBL199580 | 0.76 | TSHR (0.60) | TSHRALDH1A1TDP1LMNAHPGD | |
| SCHEMBL6908022 | 0.76 | TSHR (0.60) | TSHRALDH1A1TDP1LMNAHPGD | |
| SCHEMBL8020863 | 0.76 | TSHR (0.60) | TSHRALDH1A1MAPK1HIF1ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985572-B2 | Modified nitrilases and their use in methods for the production of carboxylic acids | BASF SE (DE) | 2011-07-26 | — | — | US | claimed |
| EP-1599584-B1 | MODIFIED NITRILASES AND THEIR USE IN METHODS FOR THE PRODUCTION OF CARBOXYLIC ACIDS | BASF SE (DE) | 2009-07-01 | — | — | EP | claimed |
| US-20060259999-A1 | Modified nitrilases and their use in methods for the production of carboxylic acids | BASF AKTIENGESELLSCHAFT (DE) | 2006-11-16 | — | — | US | claimed |
| CN-1268755-C | Process for preparing optical active cyanalcohol through enzyme catalysis alcoholysis reaction resolution | UNIV ZHEJIANG (CN) | 2006-08-09 | — | — | CN | claimed |
| EP-1599584-A1 | MODIFIED NITRILASES AND THEIR USE IN METHODS FOR THE PRODUCTION OF CARBOXYLIC ACIDS | BASF AKTIENGESELLSCHAFT (DE) | 2005-11-30 | — | — | EP | claimed |
| CN-1635129-A | Process for preparing optical active cyanalcohol through enzyme catalysis alcoholysis reaction resolution | UNIV ZHEJIANG (CN) | 2005-07-06 | — | — | CN | claimed |
| WO-2004076655-A1 | MODIFIED NITRILASES AND THEIR USE IN METHODS FOR THE PRODUCTION OF CARBOXYLIC ACIDS | BASF AKTIENGESELLSCHAFT (DE) | 2004-09-10 | — | — | WO | claimed |
| EP-0610048-B1 | Process for producing optically active alpha-hydrocarboxylic acid having phenyl group | MITSUBISHI RAYON CO (JP) | 1999-09-22 | — | — | EP | claimed |
| US-5580765-A | A CULTURE PRODUCT OF A-HYDROXYNITRILE OR A MIXTURE OF ALDEHYDE AND PRUSSIC ACID | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-12-03 | — | — | US | claimed |
| EP-0610048-A2 | Process for producing optically active alpha-hydrocarboxylic acid having phenyl group | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1994-08-10 | — | — | EP | claimed |
| US-9828594-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2017-11-28 | — | — | US | disclosed |
| US-20160355801-A1 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | VERENIUM CORPORATION | 2016-12-08 | — | — | US | disclosed |
| EP-2403842-B1 | CHIRAL DISULFONIMIDES | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 2016-06-29 | — | — | EP | disclosed |
| US-9315792-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2016-04-19 | — | — | US | disclosed |
| US-9217164-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2015-12-22 | — | — | US | disclosed |
| US-5580765-A | A CULTURE PRODUCT OF A-HYDROXYNITRILE OR A MIXTURE OF ALDEHYDE AND PRUSSIC ACID | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-12-03 | — | — | US | disclosed |
| EP-0711836-A1 | Method of producing optically active alpha-hydroxy acid or alpha-hydroxyamide | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-05-15 | — | — | EP | disclosed |
| EP-0610048-A2 | Process for producing optically active alpha-hydrocarboxylic acid having phenyl group | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1994-08-10 | — | — | EP | disclosed |
| US-4511562-A | (Thio)(dithio-phosphates(phosphonates), processes for their preparation, and their use in pest-combating agents | BAYER AKTIENGESELLSCHAFT (DE) | 1985-04-16 | — | — | US | disclosed |
| EP-0072482-A2 | (Thiono)(dithio)-phosphoric-(phosphonic)-acid esters, process for their preparation and their use as pesticides | BAYER AG (DE) | 1983-02-23 | — | — | EP | disclosed |