Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GUSB | P08236 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12599976 | 0.85 | CDK2 (0.44) | CDK2AKT1TP53GAAALDH1A1 | |
| SCHEMBL1983432 | 0.77 | KDM4E (0.51) | MAPTGAAALDH1A1KDM4EMAPK1 | |
| SCHEMBL1965273 | 0.77 | KDM4E (0.53) | CDK2MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1966150 | 0.76 | NPC1 (0.43) | MAPTGAAALDH1A1KDM4EMAPK1 | |
| SCHEMBL1980565 | 0.76 | CYP2C19 (0.36) | CDK2AKT1MAPTGAAALDH1A1 | |
| SCHEMBL1966330 | 0.75 | KDM4E (0.40) | MAPTALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1979699 | 0.74 | CPB1 (0.39) | GAAALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL1965817 | 0.74 | ALDH1A1 (0.41) | MAPTGAAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1979764 | 0.73 | S1PR1 (0.43) | MAPTGAAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1488845 | 0.73 | HPGD (0.40) | MAPTALDH1A1KDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343287-A1 | New 2-aminothiadiazole derivatives | Almirall, S.A. (ES) | 2011-07-13 | — | — | EP | disclosed |
| EP-2343287-A1 | New 2-aminothiadiazole derivatives | Almirall, S.A. (ES) | 2011-07-13 | — | — | EP | disclosed |
| WO-2011069647-A1 | NEW 2-AMINOTHIADIAZOLE DERIVATIVES | ALMIRALL, S.A. (ES) | 2011-06-16 | — | — | WO | disclosed |