Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.71 |
| ▸ | SDHB | P21912 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22912267 | 0.85 | KDM4E (0.64) | ALDH1A1SMN1; SMN2POLBKDM4EHPGD | |
| SCHEMBL19805762 | 0.85 | MAPT (0.63) | ALDH1A1SMN1; SMN2POLBKDM4EHPGD | |
| SCHEMBL22912240 | 0.83 | KDM4E (0.67) | ALDH1A1SMN1; SMN2POLBMAPK1SDHB | |
| SCHEMBL19805735 | 0.80 | KDM4E (0.66) | ALDH1A1SMN1; SMN2POLBMAPK1SDHB | |
| SCHEMBL19805710 | 0.79 | SDHB (1.00) | ALDH1A1SMN1; SMN2MAPK1SDHBKDM4E | |
| SCHEMBL29976120 | 0.79 | SDHB (1.00) | ALDH1A1SMN1; SMN2MAPK1SDHBKDM4E | |
| SCHEMBL6722321 | 0.79 | KDM4E (0.72) | ALDH1A1SMN1; SMN2POLBKDM4EHPGD | |
| SCHEMBL19806053 | 0.78 | SDHB (0.64) | ALDH1A1SMN1; SMN2POLBMAPK1L3MBTL1 | |
| SCHEMBL29975926 | 0.78 | SDHB (0.64) | ALDH1A1SMN1; SMN2POLBMAPK1L3MBTL1 | |
| SCHEMBL19805915 | 0.76 | KDM4E (0.66) | ALDH1A1SMN1; SMN2POLBMAPK1SDHB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484854-B1 | APOPTOSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-01-20 | — | — | EP | disclosed |
| WO-2018014802-A1 | APOPTOSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-01-25 | — | — | WO | disclosed |