Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6722321 | 0.88 | KDM4E (0.72) | KDM4EHPGDSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19805711 | 0.85 | ALDH1A1 (0.71) | KDM4EHPGDSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19805762 | 0.84 | MAPT (0.63) | KDM4EHPGDSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19805915 | 0.84 | KDM4E (0.66) | KDM4EHPGDSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL22912240 | 0.83 | KDM4E (0.67) | KDM4EHPGDSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19805735 | 0.81 | KDM4E (0.66) | KDM4EHPGDSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19805846 | 0.80 | KDM4E (0.67) | KDM4EHPGDSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19806036 | 0.79 | SDHB (0.71) | KDM4EHPGDSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19805743 | 0.78 | KDM4E (0.55) | KDM4EHPGDSMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL19805852 | 0.78 | KDM4E (0.57) | KDM4EHPGDSMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484854-B1 | APOPTOSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-01-20 | — | — | EP | disclosed |