Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 13/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | GRK2 | P25098 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20985645 | 0.87 | SDHB (0.45) | SDHBMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL20985733 | 0.87 | SDHB (0.49) | SDHBMAPTTP53 | |
| SCHEMBL29977013 | 0.87 | SDHB (0.45) | SDHBMAPTTP53KDM4EALDH1A1 | |
| SCHEMBL29975806 | 0.87 | SDHB (0.49) | SDHBMAPTTP53 | |
| SCHEMBL22912277 | 0.85 | SDHB (0.48) | SDHBMAPTTP53PDE2APDE3A | |
| SCHEMBL20985681 | 0.84 | SDHB (0.54) | SDHBMAPTTP53PDE4APDE4B | |
| SCHEMBL29975895 | 0.84 | SDHB (0.54) | SDHBMAPTTP53PDE4APDE4B | |
| SCHEMBL20985704 | 0.82 | SDHB (0.47) | SDHBMAPTTP53 | |
| SCHEMBL29976232 | 0.82 | SDHB (0.47) | SDHBMAPTTP53 | |
| SCHEMBL20985656 | 0.80 | SDHB (0.48) | SDHBMAPTTP53PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018014802-A1 | APOPTOSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-01-25 | — | — | WO | disclosed |