Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 2/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22761971 | 0.86 | CCR9 (0.42) | CCR9P2RX1KIF11PKMCYP3A4 | |
| SCHEMBL19806133 | 0.85 | CCR9 (0.45) | CCR9CYP2A6HTTSLC6A2SLC6A4 | |
| SCHEMBL15070880 | 0.79 | CYP2A6 (0.50) | CCR9CYP2A6P2RX1HTTHPGD | |
| SCHEMBL21094294 | 0.77 | CCR9 (0.37) | CCR9KIF11PKMESR1ESR2 | |
| SCHEMBL22414493 | 0.76 | PNMT (0.38) | CCR9KIF11PKMCYP3A4LMNA | |
| SCHEMBL20802198 | 0.75 | LMNA (0.42) | MAOBKIF11HTTALDH1A1TDP1 | |
| SCHEMBL23483734 | 0.74 | ESR1 (0.41) | KIF11HTTKCNH2ESR1ESR2 | |
| SCHEMBL19250259 | 0.74 | ESR1 (0.62) | HPGDALDH1A1TDP1CYP3A4SLC6A2 | |
| SCHEMBL18812974 | 0.74 | HTR2A (0.50) | MAOBKIF11KDM4EALDH1A1SLC6A4 | |
| SCHEMBL23479360 | 0.74 | CYP2A6 (0.48) | CCR9CYP2A6P2RX1HTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202354-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-02-12 | — | — | US | disclosed |
| US-20180022707-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180022707-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | KDM1B, KDM6B, KDM2B | CCR9 4393/4885CYP2A6 2951/4885P2RX1 3622/4885 |
| US-10202354-B2 | Therapeutic compounds and uses thereof | KDM1B, KDM6B, KDM2B | CCR9 4393/4885CYP2A6 2951/4885P2RX1 3622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.