Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SDHB | P21912 | 7/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19806077 | 0.85 | SDHB (0.50) | SDHBCYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL19806064 | 0.84 | SDHB (0.73) | SDHBL3MBTL1CREBBP | |
| SCHEMBL20985643 | 0.83 | SDHB (0.51) | SDHBL3MBTL1ADORA2AALDH1A1KDM4E | |
| SCHEMBL29976331 | 0.83 | SDHB (0.51) | SDHBL3MBTL1ADORA2AALDH1A1KDM4E | |
| SCHEMBL19805896 | 0.83 | SDHB (0.51) | SDHBCYP11B1CYP19A1CYP11B2L3MBTL1 | |
| SCHEMBL29976054 | 0.83 | SDHB (0.75) | SDHBALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL19805894 | 0.83 | SDHB (0.75) | SDHBALDH1A1KDM4EMEN1HPGD | |
| SCHEMBL19805806 | 0.81 | SDHB (0.47) | SDHBADORA2AALDH1A1KDM4EMEN1 | |
| SCHEMBL19805940 | 0.80 | MEN1 (0.45) | SDHBL3MBTL1ALDH1A1KDM4EMEN1 | |
| SCHEMBL22912257 | 0.78 | SDHB (0.49) | SDHBALDH1A1KDM4EMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3484854-B1 | APOPTOSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2021-01-20 | — | — | EP | disclosed |
| WO-2018014802-A1 | APOPTOSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-01-25 | — | — | WO | disclosed |