Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 10/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CLK3 | P49761 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1979521 | 0.89 | PIM1 (0.50) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1978967 | 0.86 | PIM1 (0.61) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1980500 | 0.81 | PIM1 (0.49) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1981543 | 0.81 | PIM1 (0.49) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1979823 | 0.80 | PIM1 (0.48) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1979380 | 0.79 | PIM1 (0.58) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1979863 | 0.78 | PIM1 (0.50) | PIM1PIM3PIM2CLK2CLK3 | |
| SCHEMBL1561286 | 0.74 | CHEK1 (0.56) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1983392 | 0.72 | PIM1 (0.45) | PIM1PIM3PIM2MAPTCHEK1 | |
| SCHEMBL1979641 | 0.72 | CHEK1 (0.63) | CHEK1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | claimed |
| WO-2011070298-A1 | DI-SUBSTITUTED 9H-PYRIDO[3,4-B]INDOLE DERIVATIVES, PREPARATION OF SAME AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-06-16 | — | — | WO | disclosed |