Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19807460 | 1.00 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL20997401 | 0.95 | TRPA1 (0.91) | TRPA1 | |
| SCHEMBL19807465 | 0.90 | TRPA1 (0.84) | TRPA1 | |
| SCHEMBL20972800 | 0.89 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL19807573 | 0.89 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL22399967 | 0.88 | TRPA1 (0.84) | TRPA1 | |
| SCHEMBL19807577 | 0.85 | TRPA1 (0.83) | TRPA1 | |
| SCHEMBL19807578 | 0.85 | TRPA1 (0.83) | TRPA1 | |
| SCHEMBL20997474 | 0.85 | TRPA1 (0.88) | TRPA1 | |
| SCHEMBL19807574 | 0.84 | TRPA1 (1.00) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10766878-B2 | Sulfonylcycloalkyl carboxamide compounds | GENENTECH, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-10766878-B2 | Sulfonylcycloalkyl carboxamide compounds | GENENTECH, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-20190144430-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS | GENENTECH, INC. (US) | 2019-05-16 | — | — | US | disclosed |
| US-20190144430-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS | GENENTECH, INC. (US) | 2019-05-16 | — | — | US | disclosed |
| WO-2018015411-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS AS TRPA1 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190144430-A1 | SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS | TRPA1, TRPV1, TRPV5 | TRPA1 1/4885 |
| US-10766878-B2 | Sulfonylcycloalkyl carboxamide compounds | TRPA1, TRPV1, TRPV5 | TRPA1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.