Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.44 |
| ▸ | ELANE | P08246 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1981009 | 1.00 | ESR1 (0.44) | ESR1CYP19A1ELANEKMT2ARECQL | |
| SCHEMBL1982008 | 0.83 | CES2 (0.50) | ESR1CYP19A1SMN1; SMN2PTGS2PGR | |
| SCHEMBL1982010 | 0.83 | CES2 (0.50) | ESR1CYP19A1SMN1; SMN2PTGS2PGR | |
| SCHEMBL1986930 | 0.81 | CYP19A1 (0.37) | ESR1CYP19A1ELANEKMT2ARECQL | |
| SCHEMBL1986932 | 0.81 | CYP19A1 (0.37) | ESR1CYP19A1ELANEKMT2ARECQL | |
| SCHEMBL12338033 | 0.81 | ELANE (0.44) | CYP19A1ELANEPPARGMAPT | |
| SCHEMBL11959193 | 0.79 | CYP19A1 (0.43) | ESR1CYP19A1KMT2ACYP3A4PTGS2 | |
| SCHEMBL12315764 | 0.79 | CYP19A1 (0.43) | ESR1CYP19A1KMT2ACYP3A4PTGS2 | |
| SCHEMBL1983042 | 0.79 | ESR1 (0.61) | ESR1KMT2ASMN1; SMN2HIF1ACYP3A4 | |
| SCHEMBL1983043 | 0.79 | ESR1 (0.61) | ESR1KMT2ASMN1; SMN2HIF1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263661-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263661-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263661-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-09-11 | — | — | US | disclosed |
| US-8236987-B2 | Selective estrogen receptor modulator compositions and methods for treatment of disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-07 | — | — | US | disclosed |
| US-8236987-B2 | Selective estrogen receptor modulator compositions and methods for treatment of disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-07 | — | — | US | disclosed |
| US-20110152226-A1 | Development of New Selective Estrogen Receptor Modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110152226-A1 | Development of New Selective Estrogen Receptor Modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110152226-A1 | Development of New Selective Estrogen Receptor Modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-06-23 | — | — | US | disclosed |
| US-20090124698-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATOR COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2009-05-14 | — | — | US | disclosed |
| US-20090124698-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATOR COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2009-05-14 | — | — | US | disclosed |
| WO-2009062082-A2 | SELECTIVE ESTROGEN RECEPTOR MODULATOR COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2009-05-14 | — | — | WO | disclosed |
| US-20080214609-A1 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-04 | — | — | US | disclosed |
| US-20080214609-A1 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-04 | — | — | US | disclosed |
| US-20080214609-A1 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-04 | — | — | US | disclosed |
| US-7196119-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196119-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196119-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-03-27 | — | — | US | disclosed |
| US-20050113453-A1 | Development of new selective estrogen receptor modulators | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214609-A1 | Development of new selective estrogen receptor modulators | ESR2, ESR1, GPER1 | ESR1 2/4885CYP19A1 13/4885ELANE 3163/4885 |
| US-20050113453-A1 | Development of new selective estrogen receptor modulators | ESR2, ESR1, GPER1 | ESR1 2/4885CYP19A1 13/4885ELANE 3163/4885 |
| US-20090124698-A1 | SELECTIVE ESTROGEN RECEPTOR MODULATOR COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASE | ESR1, GPER1, ESR2 | ESR1 1/4885CYP19A1 11/4885ELANE 1983/4885 |
| US-20110152226-A1 | Development of New Selective Estrogen Receptor Modulators | ESR2, ESR1, GPER1 | ESR1 2/4885CYP19A1 13/4885ELANE 3163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.