Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 7/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1982008 | 1.00 | CES2 (0.50) | CES2CES1ESR1ESR2CYP19A1 | |
| SCHEMBL3864916 | 0.91 | ESR1 (0.64) | CES2ESR1ESR2CYP19A1PGR | |
| SCHEMBL3864914 | 0.91 | ESR1 (0.64) | CES2ESR1ESR2CYP19A1PGR | |
| SCHEMBL3864922 | 0.91 | ESR1 (0.64) | CES2ESR1ESR2CYP19A1PGR | |
| SCHEMBL11638627 | 0.86 | CES2 (0.59) | CES2CES1ESR1ESR2CYP19A1 | |
| SCHEMBL11503437 | 0.86 | CES2 (0.59) | CES2CES1ESR1ESR2CYP19A1 | |
| SCHEMBL1981009 | 0.83 | ESR1 (0.44) | ESR1ESR2CYP19A1PGRPTGS2 | |
| SCHEMBL1981010 | 0.83 | ESR1 (0.44) | ESR1ESR2CYP19A1PGRPTGS2 | |
| SCHEMBL3654352 | 0.82 | HTR7 (0.44) | CES2CES1ESR1ESR2CYP19A1 | |
| SCHEMBL3654349 | 0.82 | HTR7 (0.44) | CES2CES1ESR1ESR2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107126660-B | Composition containing fluoroketone | 中化蓝天集团有限公司 | 2021-02-05 | — | — | CN | claimed |
| US-8263661-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263661-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-09-11 | — | — | US | disclosed |
| US-8263661-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-09-11 | — | — | US | disclosed |
| US-8236987-B2 | Selective estrogen receptor modulator compositions and methods for treatment of disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-07 | — | — | US | disclosed |
| US-8236987-B2 | Selective estrogen receptor modulator compositions and methods for treatment of disease | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-07 | — | — | US | disclosed |
| EP-2349999-A1 | ALLOSTERIC PROTEIN KINASE MODULATORS | Universität des Saarlandes (DE) | 2011-08-03 | — | — | EP | disclosed |
| US-20110152226-A1 | Development of New Selective Estrogen Receptor Modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110152226-A1 | Development of New Selective Estrogen Receptor Modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110152226-A1 | Development of New Selective Estrogen Receptor Modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-06-23 | — | — | US | disclosed |
| US-20080214609-A1 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-04 | — | — | US | disclosed |
| US-20080214609-A1 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-04 | — | — | US | disclosed |
| US-20080214609-A1 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-04 | — | — | US | disclosed |
| US-7196119-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196119-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196119-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1680101-A1 | DEVELOPMENT OF NEW SELECTIVE ESTROGEN RECEPTOR MODULATORS | The Regents of the University of California, Office of the President (US) | 2006-07-19 | — | — | EP | disclosed |
| US-20050113453-A1 | Development of new selective estrogen receptor modulators | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-05-26 | — | — | US | disclosed |
| WO-2005041946-A1 | DEVELOPMENT OF NEW SELECTIVE ESTROGEN RECEPTOR MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-05-12 | — | — | WO | disclosed |
| US-5064850-A | Anticholenergic | MARION MERRELL DOW INC. (US) | 1991-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214609-A1 | Development of new selective estrogen receptor modulators | ESR2, ESR1, GPER1 | CES2 1439/4885CES1 540/4885ESR1 2/4885 |
| US-20050113453-A1 | Development of new selective estrogen receptor modulators | ESR2, ESR1, GPER1 | CES2 1439/4885CES1 540/4885ESR1 2/4885 |
| US-20110152226-A1 | Development of New Selective Estrogen Receptor Modulators | ESR2, ESR1, GPER1 | CES2 1439/4885CES1 540/4885ESR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.