SCHEMBL198141

SCHEMBL198141

C[Si](C)(c1ccccc1)c1ccc(-c2ccc([Si](C)(C)c3ccccc3)cn2)nc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.54
ESR2 Q92731 1/20 0.54
NR1H2 P55055 2/20 0.44
NR1H3 Q13133 2/20 0.44
CCR1 P32246 2/20 0.39
CCR5 P51681 2/20 0.39
CCR8 P51685 2/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HPGD P15428 2/20 0.39
P4HTM Q9NXG6 4/20 0.34
P4HA1 P13674 1/20 0.34
LDHA P00338 2/20 0.33
BAZ2B Q9UIF8 1/20 0.33
KDM4E B2RXH2 2/20 0.32
LMNA P02545 2/20 0.32
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TP53 P04637 1/20 0.32
PKM P14618 1/20 0.32
ALOX15 P16050 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2986923 0.91 KDM4E (0.50) ESR1ESR2NR1H2NR1H3CCR1
SCHEMBL197285 0.83 CCR1 (0.39) ESR1ESR2NR1H2NR1H3CCR1
SCHEMBL12191039 0.81 ESR1 (0.75) ESR1ESR2NR1H2NR1H3HPGD
SCHEMBL196453 0.79 ESR1 (0.50) ESR1ESR2NR1H2NR1H3HPGD
SCHEMBL18540405 0.79 GABRG2 (0.43) ESR1ESR2HPGDKDM4ELMNA
SCHEMBL63526 0.78 ESR1 (0.70) ESR1ESR2NR1H2NR1H3HPGD
SCHEMBL24134538 0.78 CYP11B1 (0.48) ESR1ESR2NR1H2NR1H3LMNA
SCHEMBL193465 0.77 CCR1 (0.37) ESR1ESR2CCR1CCR5CCR8
SCHEMBL27473457 0.75 ESR1 (0.67) ESR1ESR2NR1H2NR1H3HPGD
Water SCHEMBL28099446 0.75 ESR1 (0.67) ESR1ESR2NR1H2NR1H3HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8088883-B2 Transition metal complex and process for producing conjugated aromatic compound using the transition metal complex SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-01-03 US disclosed
US-20110046336-A1 TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING CONJUGATED AROMATIC COMPOUND USING THE TRANSITION METAL COMPLEX SUMITOMO CHEMICAL COMPANY, LIMITED 2011-02-24 US disclosed
EP-2192124-A1 TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING CONJUGATED AROMATIC COMPOUND WITH THE TRANSITION METAL COMPLEX Sumitomo Chemical Company, Limited (JP) 2010-06-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110046336-A1 TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING CONJUGATED AROMATIC COMPOUND USING THE TRANSITION METAL COMPLEX C9, C5, AP1M1 ESR1 871/4885ESR2 1656/4885NR1H2 3025/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.