Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.51 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 3/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15639813 | 0.84 | TGFBR1 (0.64) | TGFBR1TRPA1 | |
| SCHEMBL15639722 | 0.82 | TGFBR1 (0.72) | TGFBR1TRPA1 | |
| SCHEMBL30117468 | 0.81 | KDR (0.47) | TGFBR1KMOFEN1 | |
| SCHEMBL15639936 | 0.81 | KDR (0.47) | TGFBR1KMOFEN1 | |
| SCHEMBL28425052 | 0.81 | TGFBR1 (0.71) | TGFBR1TRPA1 | |
| SCHEMBL15639521 | 0.81 | TGFBR1 (0.51) | TGFBR1KMOGRIN1GRIN2BTRPA1 | |
| SCHEMBL30117390 | 0.81 | TGFBR1 (0.51) | TGFBR1KMOGRIN1GRIN2BTRPA1 | |
| SCHEMBL15638787 | 0.80 | KMO (0.46) | TGFBR1KMOTNKSTNKS2GRIN1 | |
| SCHEMBL15639087 | 0.78 | TGFBR1 (0.57) | TGFBR1TRPV1TRPA1 | |
| SCHEMBL30117452 | 0.78 | TGFBR1 (0.57) | TGFBR1TRPV1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9878992-B2 | GDF-8 inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2018-01-30 | — | — | US | disclosed |