Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19817179 | 0.81 | ALDH1A1 (0.63) | ALDH1A1POLBGAAHTTCHRNB2 | |
| SCHEMBL19817181 | 0.81 | ALDH1A1 (0.63) | ALDH1A1POLBGAAHTTCHRNB2 | |
| SCHEMBL3594252 | 0.80 | ALDH1A1 (1.00) | ALDH1A1POLBGAAHTTPKM | |
| SCHEMBL3058229 | 0.79 | ALDH1A1 (0.45) | ALDH1A1POLBGAAHTTCHRNB2 | |
| SCHEMBL16044717 | 0.75 | ALDH1A1 (0.58) | ALDH1A1POLBGAACHRNB2CHRNA4 | |
| SCHEMBL17292999 | 0.72 | ALDH1A1 (0.60) | ALDH1A1POLBHTTPKMMEN1 | |
| SCHEMBL30672775 | 0.71 | PKM (0.64) | POLBCHRNB2CHRNA4PKMDGAT1 | |
| SCHEMBL14659505 | 0.71 | PKM (0.64) | POLBCHRNB2CHRNA4PKMDGAT1 | |
| SCHEMBL30555232 | 0.70 | ALDH1A1 (0.57) | ALDH1A1POLBGAAHTTPKM | |
| SCHEMBL16047686 | 0.70 | ALDH1A1 (0.57) | ALDH1A1POLBHTTPKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018020474-A1 | SUBSTITUTED THIAZOLO-PYRIDINE COMPOUNDS AS MALT1 INHIBITORS | LUPIN LIMITED (IN) | 2018-02-01 | — | — | WO | disclosed |