Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27975112 | 0.91 | LRRK2 (0.47) | LRRK2PDGFRA | |
| SCHEMBL27975393 | 0.89 | LRRK2 (0.46) | LRRK2PDGFRAABL1EGFRSRC | |
| SCHEMBL28814172 | 0.82 | LRRK2 (0.53) | LRRK2PDGFRA | |
| SCHEMBL14060259 | 0.81 | LRRK2 (0.68) | LRRK2PDGFRA | |
| SCHEMBL27975100 | 0.80 | LRRK2 (0.50) | LRRK2 | |
| SCHEMBL28830370 | 0.79 | LRRK2 (0.47) | LRRK2 | |
| SCHEMBL27975446 | 0.79 | LRRK2 (0.67) | LRRK2PDGFRA | |
| SCHEMBL28830335 | 0.78 | LRRK2 (0.70) | LRRK2PDGFRA | |
| SCHEMBL27975228 | 0.78 | LRRK2 (0.47) | LRRK2 | |
| SCHEMBL28813534 | 0.77 | LRRK2 (0.70) | LRRK2PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884828-B2 | Substituted cinnolines as inhibitors of LRRK2 kinase activity | IMAGO PHARMACEUTICALS, INC. (US) | 2018-02-06 | — | — | US | disclosed |