Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 19/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28814172 | 0.89 | LRRK2 (0.53) | LRRK2 | |
| SCHEMBL27975446 | 0.86 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL28830370 | 0.86 | LRRK2 (0.47) | LRRK2 | |
| SCHEMBL28813534 | 0.85 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL27975112 | 0.83 | LRRK2 (0.47) | LRRK2 | |
| SCHEMBL28075851 | 0.81 | LRRK2 (0.42) | LRRK2 | |
| SCHEMBL27975393 | 0.81 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059861 | 0.81 | LRRK2 (0.74) | LRRK2 | |
| SCHEMBL28830335 | 0.81 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL27975550 | 0.81 | LRRK2 (0.52) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-A | Inhibitors of LRRK2 kinase activity | ELAN PHARM INC | 2014-07-09 | — | — | CN | claimed |
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-103917525-A | Inhibitors of LRRK2 kinase activity | ELAN PHARM INC | 2014-07-09 | — | — | CN | disclosed |