Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | MELK | Q14680 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27975112 | 0.96 | LRRK2 (0.47) | LRRK2PDGFRAMELK | |
| SCHEMBL19825527 | 0.89 | LRRK2 (0.45) | LRRK2PDGFRAABL1EGFRSRC | |
| SCHEMBL28830336 | 0.83 | LRRK2 (0.43) | LRRK2PDGFRA | |
| SCHEMBL28814172 | 0.83 | LRRK2 (0.53) | LRRK2PDGFRA | |
| SCHEMBL27975446 | 0.82 | LRRK2 (0.67) | LRRK2PDGFRA | |
| SCHEMBL28830335 | 0.81 | LRRK2 (0.70) | LRRK2PDGFRA | |
| SCHEMBL27975100 | 0.81 | LRRK2 (0.50) | LRRK2 | |
| SCHEMBL27975358 | 0.81 | LRRK2 (0.68) | LRRK2PDGFRA | |
| SCHEMBL14059829 | 0.80 | LRRK2 (0.70) | LRRK2PDGFRA | |
| SCHEMBL28830370 | 0.80 | LRRK2 (0.47) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-A | Inhibitors of LRRK2 kinase activity | ELAN PHARM INC | 2014-07-09 | — | — | CN | claimed |
| CN-103917525-B | The inhibitor of LRRK2 kinase activity | 依兰制药公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-103917525-A | Inhibitors of LRRK2 kinase activity | ELAN PHARM INC | 2014-07-09 | — | — | CN | disclosed |