Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 3/20 | 0.41 |
| ▸ | USP7 | Q93009 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10980808 | 0.81 | ADRA2C (0.68) | ADRA2CPGRUSP7CLK4CNR1 | |
| SCHEMBL3536418 | 0.80 | BCL2 (0.43) | CTSSCTSKLRRK2 | |
| SCHEMBL29068276 | 0.80 | CLK4 (0.44) | ADRA2CPGRCLK4BRD4LRRK2 | |
| SCHEMBL5086336 | 0.79 | ADRA2C (0.44) | ADRA2CPGRUSP7CLK4CNR1 | |
| SCHEMBL20774359 | 0.78 | CLK4 (0.45) | ADRA2CCLK4BRD4GABRG2GABRB3 | |
| SCHEMBL5685480 | 0.77 | DPP4 (0.39) | — | |
| SCHEMBL28589926 | 0.77 | ADRA2C (0.47) | ADRA2CCLK4GABRG2GABRB3GABRA5 | |
| SCHEMBL2673331 | 0.73 | KDM4E (0.51) | ADRA2CPGRUSP7CLK4HCAR2 | |
| SCHEMBL16455741 | 0.71 | USP7 (0.50) | ADRA2CUSP7CLK4CTSSCTSK | |
| SCHEMBL1202557 | 0.71 | CLK4 (0.50) | ADRA2CPGRCLK4GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509978-A1 | AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | E.I. Du Pont De Nemours And Company (US) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011072207-A1 | AZOCYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2011-06-16 | — | — | WO | disclosed |