SCHEMBL1983158

SCHEMBL1983158

CC(NC(=O)c1cnc(NC(=O)OC(C)(C)C)s1)C1CCC1

nearest known ligand 0.39

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LCK P06239 7/20 0.39
MAPK14 Q16539 4/20 0.39
SMYD3 Q9H7B4 2/20 0.39
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
FPR3 P25089 2/20 0.37
FPR2 P25090 2/20 0.37
METAP1 P53582 1/20 0.37
ACACB O00763 3/20 0.36
MAPK13 O15264 1/20 0.36
EGFR P00533 1/20 0.36
FYN P06241 1/20 0.36
HCK P08631 1/20 0.36
SRC P12931 1/20 0.36
JAK3 P52333 1/20 0.36
MAPK12 P53778 1/20 0.36
MAPK11 Q15759 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1987487 0.97 LCK (0.39) LCKSMYD3CA1CA2FPR3
SCHEMBL19914222 0.82 LCK (0.43) LCKMAPK14CA1CA2FPR3
SCHEMBL1989018 0.78 HDAC3 (0.44) LCKMAPK14FPR3FPR2
SCHEMBL949743 0.77 CA1 (0.44) LCKMAPK14CA1CA2METAP1
SCHEMBL27360278 0.77 CCNE1 (0.43) LCKCA1CA2METAP1
SCHEMBL1986003 0.76 SMYD3 (0.46) SMYD3CA1CA2ACACBJAK3
SCHEMBL1990109 0.75 LCK (0.53) LCK
SCHEMBL29632538 0.75 KDM4E (0.51) LCKMAPK14MAPK13MAPK12MAPK11
SCHEMBL12715493 0.74 CCNE1 (0.50) LCKCA1CA2
SCHEMBL951493 0.74 CA1 (0.46) LCKCA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2222655-B1 N-CYCL0ALKYLMETHYL-2-AMIN0THIAZ0LE-5-CARB0XAMIDES FOR USE IN PLANT DISEASE CONTROL SUMITOMO CHEMICAL CO (JP) 2011-06-29 EP disclosed
EP-2222655-B1 N-CYCL0ALKYLMETHYL-2-AMIN0THIAZ0LE-5-CARB0XAMIDES FOR USE IN PLANT DISEASE CONTROL SUMITOMO CHEMICAL CO (JP) 2011-06-29 EP disclosed
US-20100298391-A1 AMIDE COMPOUNDS AND USE THEREOF FOR PLANT DISEASE CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-11-25 US disclosed
US-20100298391-A1 AMIDE COMPOUNDS AND USE THEREOF FOR PLANT DISEASE CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-11-25 US disclosed
US-20100298391-A1 AMIDE COMPOUNDS AND USE THEREOF FOR PLANT DISEASE CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-11-25 US disclosed
EP-2222655-A1 N-CYCL0ALKYLMETHYL-2-AMIN0THIAZ0LE-5-CARB0XAMIDES FOR USE IN PLANT DISEASE CONTROL Sumitomo Chemical Company, Limited (JP) 2010-09-01 EP disclosed
WO-2009066790-A1 N-CYCL0ALKYLMETHYL-2-AMIN0THIAZ0LE-5-CARB0XAMIDES FOR USE IN PLANT DISEASE CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-05-28 WO disclosed
WO-2009066790-A1 N-CYCL0ALKYLMETHYL-2-AMIN0THIAZ0LE-5-CARB0XAMIDES FOR USE IN PLANT DISEASE CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-05-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100298391-A1 AMIDE COMPOUNDS AND USE THEREOF FOR PLANT DISEASE CONTROL CYC1, NAT1, CYCS LCK 2767/4885MAPK14 1800/4885SMYD3 323/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.