Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 6/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.53 |
| ▸ | EP300 | Q09472 | 5/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22474043 | 0.92 | CREBBP (0.62) | CREBBPBRD4EP300MAPK1RBP4 | |
| SCHEMBL20053806 | 0.88 | CREBBP (0.50) | CREBBPBRD4EP300MAPK1KDR | |
| SCHEMBL20952900 | 0.87 | CREBBP (0.41) | CREBBPBRD4EP300KDRRBP4 | |
| SCHEMBL17518082 | 0.85 | CREBBP (0.54) | CREBBPBRD4EP300MAPK1HCAR2 | |
| SCHEMBL16123826 | 0.84 | CREBBP (0.46) | CREBBPBRD4EP300RBP4 | |
| SCHEMBL17234776 | 0.84 | RIPK1 (0.43) | CREBBPBRD4EP300PARP1MAPK1 | |
| SCHEMBL21334029 | 0.84 | CREBBP (0.40) | CREBBPBRD4EP300MAPK1RBP4 | |
| SCHEMBL17229760 | 0.83 | CREBBP (0.52) | CREBBPBRD4EP300MAPK1HCAR2 | |
| SCHEMBL19413392 | 0.80 | CREBBP (0.49) | CREBBPBRD4EP300MAPK1HCAR2 | |
| SCHEMBL19413418 | 0.79 | CREBBP (0.48) | CREBBPBRD4EP300MAPK1RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180030060-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030060-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HRH4, HRH3, HRH2 | CREBBP 1412/4885BRD4 57/4885EP300 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.