Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 4/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | RBP4 | P02753 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | EP300 | Q09472 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19413418 | 0.93 | CREBBP (0.48) | CREBBPBRD4RBP4EP300POLB | |
| SCHEMBL19831875 | 0.87 | CREBBP (0.53) | CREBBPBRD4RBP4KDREP300 | |
| SCHEMBL16123824 | 0.86 | RBP4 (0.43) | CREBBPBRD4RBP4EP300POLB | |
| SCHEMBL17518081 | 0.85 | CREBBP (0.40) | CREBBPBRD4RBP4KDREP300 | |
| SCHEMBL17465959 | 0.85 | CREBBP (0.40) | CREBBPBRD4RBP4KDREP300 | |
| SCHEMBL20053806 | 0.83 | CREBBP (0.50) | CREBBPBRD4KDREP300 | |
| SCHEMBL20696228 | 0.80 | CREBBP (0.42) | CREBBPBRD4RBP4EP300DPP4 | |
| SCHEMBL21334029 | 0.80 | CREBBP (0.40) | CREBBPBRD4RBP4EP300POLB | |
| SCHEMBL17234776 | 0.80 | RIPK1 (0.43) | CREBBPBRD4EP300 | |
| SCHEMBL22474043 | 0.79 | CREBBP (0.62) | CREBBPBRD4RBP4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10273243-B2 | 4-phenylpiperidines, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10273243-B2 | 4-phenylpiperidines, their preparation and use | HTR3C, HRH4, CYP4F3 | CREBBP 1636/4885BRD4 10/4885RBP4 2619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.