Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 14/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 9/20 | 0.55 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.55 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17234787 | 0.86 | CHRM3 (0.46) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL4349594 | 0.81 | CHRM3 (0.50) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL19033501 | 0.81 | CHRM3 (0.50) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL10652697 | 0.80 | CHRM3 (0.59) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL4115773 | 0.76 | CHRM3 (0.59) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL10654776 | 0.75 | CHRM3 (0.97) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL3441412 | 0.74 | CHRM3 (0.47) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL10652956 | 0.73 | CHRM3 (1.00) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL4339111 | 0.73 | CHRM3 (0.46) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL13061758 | 0.73 | SMN1; SMN2 (0.42) | CHRM3CHRM5CHRM1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180030060-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-02-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180030060-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HRH4, HRH3, HRH2 | CHRM3 61/4885CHRM5 129/4885CHRM1 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.