Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 14/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 9/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3441412 | 0.87 | CHRM3 (0.47) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL19831902 | 0.73 | CHRM3 (0.58) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL4349594 | 0.70 | CHRM3 (0.50) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL19033501 | 0.70 | CHRM3 (0.50) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL2586360 | 0.69 | LMNA (0.67) | CHRM3 | |
| SCHEMBL16221083 | 0.69 | CHRM3 (0.56) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL10652697 | 0.69 | CHRM3 (0.59) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL455554 | 0.64 | CHRM3 (0.59) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL4115773 | 0.64 | CHRM3 (0.59) | CHRM3CHRM5CHRM1CHRM2CHRM4 | |
| SCHEMBL16220619 | 0.64 | CHRM3 (0.54) | CHRM3CHRM5CHRM1CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268814-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-8268814-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-8268814-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| US-20090275558-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-11-05 | — | — | US | disclosed |
| US-20090275558-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-11-05 | — | — | US | disclosed |
| US-20090275558-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GRUENENTHAL GMBH (DE) | 2009-11-05 | — | — | US | disclosed |
| WO-2009124746-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275558-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | BDKRB2, BDKRB1, TRPV1 | CHRM3 1235/4885CHRM5 2057/4885CHRM1 1433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.